Metafolin is a trademarked name for the active form of folate, known as methylfolate. While Optimized Folate doesn't utilize this specific brand, it does include L-Methylfolate.

Life ExtensionOptimized Folate (L-Methylfolate) – Supports Heart & Brain Health – Non-GMO, Gluten-Free, Vegetarian –1700 mcg DFE — 100 Vegetarian Tablets

Life ExtensionOptimized Folate (L-Methylfolate) – Supports Heart & Brain Health – Non-GMO, Gluten-Free, Vegetarian –1700 mcg DFE — 100 Vegetarian Tablets

Q: It says 1700 mcf DFE of folate, but how of that is actual folic acid equivalent?

Hello, We apologize for any confusion. At the end of August of 2020, we updated our Optimized Folate supplement facts section. The amount of folate was updated from 1,000 mcg to 1,700 mcg based on updated FDA labeling guidelines. This change is a result of what the FDA has defined as dietary folate equivalents (DFE). They determined that 0.6 mcg of (6S)-5-methyltetrahydrofolate, calcium salt is equal to 1 mcg DFE. They have also determined that one mcg of naturally occurring folate is equal to one mcg DFE. Their rationale is that this accounts for the greater bioavailability (6S)-5-methyltetrahydrofolate, calcium salt compared to naturally occurring folate. The change to 1,700 mcg in this product allows us to deliver the desired potency in terms of DFE.

Q: What is the expiration date?

The expiration date on mine is 7/20/2023, but I bought it over 3 months ago. I have no idea what the expiration date will be on the bottle you’re buying.

Q: Is any component of your usa manufactured product sourced from china or india?

It's been a very long time since I purchased this product. I no longer have the container and have consumed all of the product. That said, I have since switched to Folic Acid 800 mcg made in Austin Texas and available on Amazon.

Product ID: 258199059

Secure Transaction

Details

Brand
Life Extension
Item form
Tablet
Primary supplement type
Folate as salt
Diet type
Gluten Free
Flavour
Unflavored

💊1700 mcg bioactive 5-MTHF

🧠Supports cognitive & neurotransmitter health

❤️Maintains healthy homocysteine for heart

Frequently Bought Together

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

Life Extension TMG 500 mg – Trimethylglycine Supplement – Encourages Healthy Homocysteine Levels – Gluten-free – Non-gmo – Vegetarian – 60 Liquid Vegetarian Capsules

Life Extension Neuro-Mag Magnesium L-Threonate, Magnesium L-threonate, Memory Health, Quick Thinking, Cognitive Health Support, Vegetarian, Non-GMO, 90 Vegetarian Capsules

Description

💡 Elevate your heart and mind with every tablet — don’t miss out on optimized wellness!

PURE CLEAN FORMULA - Non-GMO, gluten-free, vegetarian tablets crafted with premium ingredients
SCIENCE BACKED EFFICACY - Formulated based on 40+ years of research for maximum absorption and impact
DAILY WELLNESS MADE SIMPLE - One tablet a day keeps your heart and mind in peak condition
DUAL BRAIN HEART SUPPORT - Optimized to maintain homocysteine levels linked to cardiovascular and cognitive health
BIOACTIVE FOLATE POWERHOUSE - 1700 mcg of 5-MTHF, up to 7x more bioavailable than folic acid

Life Extension Optimized Folate delivers 1700 mcg of metabolically active L-Methylfolate (5-MTHF) per vegetarian tablet, supporting healthy homocysteine levels for cardiovascular and cognitive health. Non-GMO, gluten-free, and backed by decades of scientific research, this supplement ensures superior bioavailability and purity for daily brain and heart support.

Specifications

Product Name	L-Methylfolate Supplement
Additives	microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.
Allergen Information	Gluten Free, Non-GMO
Weight	0.2 Kilograms
Units	100 Count
Serving Recommendation	Take one (1) tablet daily
Brand	Life Extension
Format	Tablet
Age Range Description	Adult

Have a Question? See What Others Asked

It says 1700 mcf DFE of folate, but how of that is actual folic acid equivalent?

What is the expiration date?

Is this Metafolin?

Is any component of your usa manufactured product sourced from china or india?

Common Questions

Are the products genuine and authentic?+

Yes, all products are sourced directly from authorized retailers in the US, UK, UAE and India. We maintain strict quality control processes and verify each product before shipping. All items come with applicable manufacturer warranties and are covered by our standard return policy.

How long does delivery take and is it reliable?+

Delivery times vary by destination country, typically ranging from 3-9 business days. Each order is fully trackable through our system. We handle all customs clearance and use reliable courier partners for last-mile delivery. You'll receive regular updates about your order status via email and our app.

What is Desertcart? Is it safe to order from?+

Desertcart is an international e-commerce platform operating since 2014. We securely process thousands of orders globally each day. Every product goes through our quality verification process before delivery, and we provide end-to-end order tracking, 24/7 customer support, and a comprehensive returns policy to ensure a safe shopping experience.

How is product pricing calculated?+

Our prices include the product cost, international shipping, import duties, customs clearance, and local delivery charges. We handle all customs and import procedures, ensuring there are no hidden fees upon delivery. PRO members receive additional benefits including free shipping.

Trustpilot

TrustScore 4.5 | 7,300+ reviews

Shop Global, Save with Desertcart

Value for Money

Competitive prices on a vast range of products

Shop Globally

Serving millions of shoppers across more than 100 countries

Enhanced Protection

Trusted payment options loved by worldwide shoppers

Customer Assurance

Trusted payment options loved by worldwide shoppers.

Desertcart App