Super Agers: An Evidence-Based Approach to Longevity

This book is a must have. Seriously. I think this is the 7th copy I have ordered for myself and for friends and colleagues. How good is it? Well, I am currently temporarily on crutches and ordered a copy for all 3 floors in our house so I could have one on every floor to read and reread when I have time (which I have more of now because of the crutches)This book is a totally evidence based discussion of current realities based on data and current fads/misrepresentations of data or lack of data when it comes to aging. The focus is on healthier living with a full life mentally and physically and NOT necessarily living longer if it is meaningless life.As an MD with a Ph.D. in nutrition, I am very, very picky about books I give to friends, other physicians, and/or recommend. This one is high on the list of must reads. I would love to see Drs. Topol and Attia discuss the topics covered in this book on joint podcasts.Get this one and keep an open mind. You will NOT be disappointed.

I love Eric Topol’s new book *Super Agers*—it could just as easily be called *Evidence-Based Preventive Medicine 2025*. It’s deeply grounded in the literature, refreshingly free of hype, and Topol is always clear about study quality without overpromising. Given all the snake oil out there, it can be hard to know which news or press sources are credible - this one is not in doubt. His careful citations and well-established track record—through both his podcast and prolific publications—leave the reader confident in the veracity of his claims and the thoughtfulness of his conclusions. Many of the ideas he presents are genuinely exciting and may indeed help reduce disease burden and extend health span. The chapter on environmental mediators of disease and health span is exceptional—filled with insights I’ll be incorporating into how I think about my own diet.

As you can see, this is not a bunch of opinions, this is evidence based. I’ve been following Dr. total for a long time on Twitter, and I credit his advice for keeping my blood pressure under control and for my rapid recovery from a thoracotomy. I just can’t say enough about this book and how it will help you live not longer but live better through the days you’ve been given. Thank you Dr. Topal for writing such a fabulous book. You know you are loved by a lot of people.

In Super Agers, renowned cardiologist Eric Topol offers a sweeping, densely packed guide to the evolving science of longevity. Topol’s central mission is clear: to show how modern medicine—bolstered by genomics, pharmacology, and AI—may allow many of us not simply to live longer, but to delay the onset of chronic disease and enjoy an extended healthspan.The book brims with valuable, up-to-the-minute insights, yet prospective readers should be forewarned: Super Agers is no breezy popular science title. Large sections read more like rigorous academic reviews than general-interest prose. Topol marshals hundreds of studies and showers the reader with specialized terminology, technical data, and acronyms, many of which would likely bewilder even the most diligent, college-educated audience. Skimming, rather than savoring, may become a survival strategy for many readers.Given Topol’s professional roots, it is no surprise that his discussion of cardiovascular disease prevention is among the book’s strongest and clearest contributions. By contrast, the opening to Chapter 6, which addresses cancer, is strikingly disjointed—an odd lapse in an otherwise meticulously constructed narrative.Among the most revelatory sections is Topol’s exploration of GLP-1 receptor agonists, a class of drugs already famous for their role in diabetes and obesity treatment. Topol convincingly argues that their potential impact extends much further, suggesting they may reshape the landscape of medicine itself. “The impact of GLP-1 drugs in medicine—for improving patient outcomes—will likely be more substantial than any prior class of medications,” he writes, noting their “major triumph” in combining high efficacy with favorable safety profiles. At one point, Topol even speculates that “it is conceivable that most people will be taking one of the GLP-1 drugs in the future.” It’s a bold assertion, but one he supports with considerable evidence.Topol’s scholarly rigor is reinforced by an exhaustive list of references, although the unconventional note system—linking citations to chapter and page numbers rather than traditional footnotes—and the minuscule font size used for these notes are sure to frustrate anyone wishing to dive deeper without a magnifying glass.The ultimate question, then, is: for whom was this book written? Despite its glossy cover and broad promises, Super Agers seems best suited to practicing physicians, researchers, and highly motivated lay readers with a tolerance for complexity. Those willing to persevere will be rewarded with a bracing, if at times arduous, journey through the cutting edge of preventive medicine.Super Agers may not offer an easy path to a longer life, but it is a serious guide for those determined to understand—and perhaps seize—the promise of modern longevity science.